Cerebral palsy in twins: a national study.

نویسندگان

  • P O D Pharoah
  • T S Price
  • R Plomin
چکیده

BACKGROUND Cerebral palsy is more common in twins than singletons. Among twins, if one twin suffers a fetal death or dies in infancy, the prevalence of cerebral palsy in the surviving co-twin is considerably increased, and those from like-sex pairs are particularly at high risk. AIM To compare birthweight specific cerebral palsy prevalence in like-sex and unlike-sex twins where both twins survive infancy and to provide a comparative and composite picture of cerebral palsy prevalence according to whether a co-twin died or where both twins survived. METHODS Parents of twins born in England and Wales in 1994 and 1995 completed a booklet with open ended questions asking whether their twins had any medical, physical, visual, genetic, or chromosomal problems. Any mention of cerebral palsy, hemiplegia, diplegia, or quadriplegia allowed the child to be included as a case of cerebral palsy. Birthweight specific prevalence rates of cerebral palsy were determined for like and unlike-sex twins in birthweight groups < 1000 g, 1000-1499 g, 1500-1999 g, 2000-2499 g, and > or = 2500 g. RESULTS When both twins survived infancy, like-sex were at greater risk of cerebral palsy than unlike-sex twins, but the difference was not statistically significant. If both twins survived infancy, the birthweight specific prevalence of cerebral palsy was significantly less than if the co-twin had died. CONCLUSIONS Among the generality of twins, like-sex compared with unlike-sex twins are at greater risk of cerebral palsy particularly if one twin suffers a fetal or infant death. Although it is not possible to subdivide the twins according to zygosity, it is postulated that monozygosity and, specifically, monochorionicity may be the crucial feature that leads to the higher prevalence of cerebral impairment among like-sex twins.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Neurological sequelae in twins born after assisted conception: controlled national cohort study.

OBJECTIVE To compare neurological sequelae in twins born after assisted conception with singletons after assisted conception and naturally conceived twins and to assess neurological sequelae in children conceived after in vitro fertilisation (IVF) compared with intracytoplasmic sperm injection (ICSI). DESIGN Controlled, national register based, cohort study. PARTICIPANTS Twins (n = 3393) an...

متن کامل

Cerebral palsy in the surviving twin associated with infant death of the co-twin.

BACKGROUND Monozygotic twins are at greater risk of dying and of serious morbidity than dizygotic twins, and both are at greater risk than singletons. This is only partly explained by the higher proportion of low birthweight infants among twins. AIM To compare, in same sex and different sex twins, birth weight specific neonatal death rates and cerebral palsy prevalence rates in the surviving ...

متن کامل

Etiology of cerebral palsy in children in rehabilitation centers, Mashad, Iran

Introduction: Cerebral palsy is defined as a movement disorder in the first years of life which is not progressive and is due to permanent cerebral damages. Most of these movement disorders are preventable. The aim of this study is investigation on the probable etiology of cerebral palsy of children in Mashhad, Iran. Methods: In this descriptive study, 5 rehabilitation centers in Mashhad city w...

متن کامل

The incidence of twins in cerebral palsy and mental retardation.

There is evidence that there is a higher incidence of mental retardation and of cerebral palsy among children born from a multiple pregnancy than among singletons. Asher and Schonell (1950) found that 5 * 4% of their 400 cases of cerebral palsy were members of twins. Greenspan and Deaver (1953) found that 7% of their 94 cases resulted from multiple pregnancies. The corresponding figure in Shyh-...

متن کامل

Twins, triplets, and cerebral palsy in births in Western Australia in the 1980s.

OBJECTIVES To examine the rate of cerebral palsy in twins and triplets in births from 1980 to 1989 in Western Australia and to identify factors associated with increase in risk. DESIGN Pluralities for all births in Western Australia were identified through the standardised midwives' notification system, and cases of cerebral palsy were identified from the Western Australian cerebral palsy reg...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Archives of disease in childhood. Fetal and neonatal edition

دوره 87 2  شماره 

صفحات  -

تاریخ انتشار 2002